Brian G Sutherland Selected Research

didemnins

11/2020	The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
1/2016	Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice.

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Brian G Sutherland Research Topics

Disease

11	Insulin Resistance 01/2022 - 10/2009
9	Atherosclerosis 01/2022 - 04/2010
8	Inflammation (Inflammations) 11/2020 - 03/2013
8	Obesity 11/2020 - 04/2010
6	Dyslipidemias (Dyslipidemia) 01/2020 - 10/2009
5	Hyperlipidemias (Hyperlipidemia) 01/2022 - 04/2010
5	Hyperinsulinism (Hyperinsulinemia) 06/2015 - 10/2009
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018 - 10/2009
3	Non-alcoholic Fatty Liver Disease 12/2020 - 01/2016
2	Fibrosis (Cirrhosis) 11/2020 - 01/2019
2	Ischemia 01/2019 - 01/2016
2	Body Weight (Weight, Body) 01/2019 - 01/2017
2	Hyperglycemia 01/2014 - 01/2014
1	Weight Loss (Weight Reduction) 12/2020
1	Weight Gain 01/2019
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2018
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Hypoxia (Hypoxemia) 01/2016
1	Vascular Diseases (Vascular Disease) 01/2016
1	Vascular System Injuries 01/2016
1	Glucose Intolerance 06/2015
1	Hepatocellular Carcinoma (Hepatoma) 05/2011

Drug/Important Bio-Agent (IBA)

8	LipidsIBA 12/2020 - 03/2013
7	naringeninIBA 01/2019 - 10/2009
6	FlavonoidsIBA 01/2022 - 04/2010
6	Glucose (Dextrose)FDA LinkGeneric 12/2020 - 10/2009
6	CholesterolIBA 01/2019 - 10/2009
5	Lipoproteins (Lipoprotein)IBA 01/2022 - 10/2009
4	nobiletinIBA 01/2022 - 05/2011
4	LDL Receptors (LDL Receptor)IBA 01/2018 - 10/2009
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 10/2009
3	Triglycerides (Triacylglycerol)IBA 11/2020 - 10/2009
3	ApolipoproteinsIBA 05/2011 - 10/2009
2	didemninsIBA 11/2020 - 01/2016
2	Proteins (Proteins, Gene)FDA Link 11/2020 - 01/2016
2	Niacin (Nicotinic Acid)FDA LinkGeneric 01/2019 - 01/2016
2	8- hydroxy- 2,2,14,14- tetramethylpentadecanedioic acidIBA 01/2018 - 01/2017
2	Insulin (Novolin)FDA Link 01/2014 - 05/2011
2	GW 501516IBA 01/2014 - 01/2014
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2014 - 10/2009
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2022
1	Peptide Elongation Factors (Elongation Factor)IBA 11/2020
1	Vitamin D FDA LinkGeneric 01/2019
1	LDL CholesterolIBA 01/2018
1	oxidized low density lipoproteinIBA 01/2018
1	ATP Citrate (pro-S)-Lyase (Citrate Synthase, ATP)IBA 01/2017
1	Oxygen (Dioxygen)IBA 01/2016
1	Biological ProductsIBA 01/2016
1	Endoplasmic Reticulum Chaperone BiPIBA 01/2016
1	matrigelIBA 01/2016
1	fibroblast growth factor 21IBA 06/2015
1	Dietary CholesterolIBA 03/2013
1	very low density lipoprotein triglycerideIBA 05/2011
1	Cholesterol Esters (Cholesteryl Esters)IBA 10/2009
1	Sterol Regulatory Element Binding Protein 1IBA 10/2009
1	PPAR gammaIBA 10/2009
1	PPAR alphaIBA 10/2009

Therapy/Procedure

2	Caloric Restriction 12/2020 - 01/2016
2	Therapeutics 01/2018 - 01/2016
1	Injections 01/2016
1	Fat-Restricted Diet (Diet, Fat Restricted) 03/2013